KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
15.76
Human Site:
S219
Identified Species:
24.76
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.43
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S219
T
T
Y
V
T
D
K
S
E
E
D
N
E
I
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S219
T
T
Y
V
T
D
K
S
E
E
D
N
E
I
E
Dog
Lupus familis
XP_531814
1283
145094
S202
G
S
S
D
E
I
S
S
G
V
G
D
S
D
S
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S219
E
A
Y
L
S
D
K
S
E
E
D
N
Y
N
E
Rat
Rattus norvegicus
XP_002726765
1361
151628
S222
G
A
Y
L
S
D
K
S
E
E
E
N
Q
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
E323
D
T
E
E
A
E
E
E
E
M
E
Q
F
V
S
Frog
Xenopus laevis
NP_001089247
1340
149481
S202
M
E
V
E
E
N
S
S
A
S
H
D
E
E
V
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
E221
D
A
E
M
S
E
E
E
V
K
E
K
T
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
A124
Y
E
P
D
E
N
E
A
S
D
D
S
V
S
S
Honey Bee
Apis mellifera
XP_392346
1120
127429
E54
K
T
P
S
K
G
K
E
N
K
N
L
E
D
R
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
E120
A
S
D
C
E
V
V
E
S
P
E
S
T
P
Q
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
I201
G
S
A
S
E
E
D
I
T
I
R
R
R
K
P
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
E209
E
D
W
G
K
N
A
E
K
D
V
S
E
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
S202
L
R
K
V
V
T
D
S
D
D
D
V
E
M
G
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
D176
D
E
D
E
Y
L
P
D
K
N
D
G
D
E
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
60
53.3
N.A.
N.A.
13.3
13.3
0
N.A.
6.6
20
0
0
P-Site Similarity:
100
N.A.
100
20
N.A.
73.3
80
N.A.
N.A.
40
26.6
40
N.A.
40
33.3
26.6
13.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
46.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
20
7
0
7
0
7
7
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
7
14
14
0
27
14
7
7
20
40
14
7
20
7
% D
% Glu:
14
20
14
20
34
20
20
34
34
27
27
0
40
20
34
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
20
0
0
7
0
7
0
0
7
0
7
7
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
7
0
7
0
0
0
14
0
% I
% Lys:
7
0
7
0
14
0
34
0
14
14
0
7
0
14
0
% K
% Leu:
7
0
0
14
0
7
0
0
0
0
0
7
0
0
0
% L
% Met:
7
0
0
7
0
0
0
0
0
7
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
20
0
0
7
7
7
27
0
7
0
% N
% Pro:
0
0
14
0
0
0
7
0
0
7
0
0
0
7
14
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
7
7
0
7
% Q
% Arg:
0
7
0
0
0
0
0
0
0
0
7
7
7
0
7
% R
% Ser:
0
20
7
14
20
0
14
47
14
7
0
20
7
7
20
% S
% Thr:
14
27
0
0
14
7
0
0
7
0
0
0
14
0
0
% T
% Val:
0
0
7
20
7
7
7
0
7
7
7
7
7
7
7
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
27
0
7
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _